International Urology Journal Club (@iurojc) returned to Twitter, December 2nd through 4th, 2012. The 48-hour Tweet Chat, hashtag #urojc, was hosted by Dr. Henry Woo (@DrHWoo) and his colleagues in Sydney, Australia.
The focus of the December journal club was the soon to be published, randomized, European study on maintenance Bacillus Calmette-Guerin (BCG) therapy for high risk Ta and T1 bladder cancer.
BCG – A Brief History
An excellent review article on the history of BCG in the treatment of bladder cancer has previously been published by Dr. Henry Herr and Dr. Alvoaro Morales.
Briefly, BCG is an attenuated (nonvirulent) form of Mycobacterium bovis cultured in 1921 by Albert Calmette and Camille Guerin at the Pasteur Institute in Lille, France. In the late 1920’s, autopsy studies performed at Johns Hopkins Hospital in Baltimore, Maryland, showed a lower frequency of cancer in patients with tuberculosis. In the years that followed, attempts were made to use BCG against a variety of human cancer tumors with only limited success. It wasn’t until the 1970’s, however, that a Canadian urologist, Dr. Alvaro Morales, began his groundbreaking work on the use of intravesical BCG for the treatment of superficial bladder cancer. Over 30 years later, BCG continues to be used worldwide for the treatment of high grade noninvasive bladder cancer.
Discussion and Debate Take Place
Representative from four continents participated in this month’s #urojc discussion. The continent of Africa was represented Dr. Ayman Rashed (@DrAymanRashed) Cairo, Egypt.
The primary author of the paper, Dr. Jorg Joddens (@Joddens) of the Netherlands, was an active participant throughout the discussion and available to answer questions about the paper. A variety of issues were discussed during the 2-day #urojc discussion including optimal dose, tolerability and side effects, and compliance with BGC maintenance therapy. Indications for early cystectomy were also discussed.
Winner of “Best Tweet”
Dr. Ben L. Jackson (@Ben_L_Jackson), a urologist-in-training from Derby, United Kingdom, was awarded the Best Tweet of the discussion. Nature Reviews in Urology sponsored the prize; a one-year online subscription to the journal. Dr. Jackson now joins November winner Dr. Benjamin Davis (@daviesbj) in the prestigious “Best Tweet” hall of fame.
#UROJC Transcript and Analytics
Up Next: January’s Urology Journal Club on PHI
The next #urojc Tweet Chat will take place on Twitter, January 6th through 8th, 2013. The paper for January is the “Prospective, Multi-Center Evaluation of the Beckman Coulter Prostate Health Index Using WHO Calibration” in the Journal of Urology by Dr. Stacy Loeb (@LoebStacy), et al. You can also access via PubMed, or for more information send a Direct Message to the @iurojc via Twitter.
For me, in Michigan, the chat will start on Sunday afternoon, January 6th, at 3:00 pm EST. The corresponding time in Sydney for Dr. Woo and Australian friends will be Monday morning, January 7th, at 7:00 am EDT time. For the time in your part of the world, see the World Clock. See you then!